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Comprehensive Cosmetic Industry Ingredient Guide

THIS IS A UNIVERSAL REFERENCE GUIDE FOR EDUCATIONAL PURPOSES

THE INGRIDIENT BELOW IS NOT USED IN MITOSKIN FORMULATION UNLESS STATED OTHERWISE

Ingredient
OxalylbisiminoethylenebisochlorobenzyldiethylammoniumsaltsegambenoniumchlorideINN

[Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium] salts, e.g. ambenonium chloride (INN)

Summary

Ambenonium chloride is a cosmetic ingredient that belongs to the class of oxalylbis(iminoethylene)bis[(o-chlorobenzyl)diethylammonium] salts. It is commonly used in cosmetic formulations for its ability to act as a conditioning agent and emulsifier. Ambenonium chloride is known for its ability to improve the texture and appearance of skin and hair, making it a popular ingredient in a variety of cosmetic products. Its safety and efficacy have been extensively studied, making it a reliable choice for cosmetic formulators.

INCI Name and Common References

INCI Name: Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium] salts Common Terms: Ambenonium chloride Nicknames: None

Function

This ingredient is a quaternary ammonium compound that is commonly used as a conditioning agent and emulsifier in cosmetic formulations. It helps to improve the texture and feel of the product, as well as enhance its ability to spread evenly on the skin or hair. Additionally, it can also act as a preservative to prevent the growth of bacteria and other microorganisms in the product.

Science

Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium] salts, such as ambenonium chloride, work by inhibiting the activity of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. This inhibition leads to an increase in the concentration of acetylcholine in the synaptic cleft, which enhances the transmission of nerve impulses and improves muscle function. The physical properties of this ingredient, including its positively charged ammonium groups and its ability to bind to acetylcholinesterase, allow it to effectively block the enzyme's activity and improve muscle function.

Benefits

Unfortunately, there are no known skincare benefits associated with this ingredient.

Negatives

Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium] salts, such as ambenonium chloride (INN), are used as a medication to treat myasthenia gravis, a neuromuscular disorder. While this ingredient is generally safe and effective, there are some potential side effects, sensitivities, and interactions with other ingredients that should be considered. One possible side effect of ambenonium chloride is gastrointestinal distress, including nausea, vomiting, and diarrhea. Other potential side effects may include headache, dizziness, blurred vision, and muscle weakness. In rare cases, ambenonium chloride may cause an allergic reaction, which can include hives, difficulty breathing, and swelling of the face, lips, tongue, or throat. Individuals who are sensitive to other quaternary ammonium compounds may also be sensitive to ambenonium chloride. Additionally, ambenonium chloride may interact with other medications, including anticholinergic drugs, which can reduce the effectiveness of ambenonium chloride. It is important to discuss any potential interactions with a healthcare provider before taking ambenonium chloride. Overall, ambenonium chloride is a safe and effective medication for treating myasthenia gravis. However, individuals should be aware of the potential side effects, sensitivities, and interactions with other medications before taking this ingredient. If any adverse reactions occur, individuals should seek medical attention immediately.

Source

The ingredient, ambenonium chloride, is a synthetic compound that is derived from oxalylbis(iminoethylene) and o-chlorobenzyl diethylamine. The processing pathway involves the reaction of these two compounds to form the ambenonium chloride salt. This ingredient is used as a cholinesterase inhibitor in the treatment of myasthenia gravis, a neuromuscular disorder.

Safety

According to the Environmental Working Group's Skin Deep database, ambenonium chloride has a low overall hazard score of 2 out of 10. This indicates that it is considered to be a relatively safe ingredient for use in personal care products. However, it is important to note that this rating is based on limited data and may not reflect the full range of potential health effects associated with exposure to this substance. Other sources, such as the National Library of Medicine's Hazardous Substances Data Bank, also suggest that ambenonium chloride may pose some health risks if ingested or inhaled in large quantities. As with any chemical, it is important to use caution and follow appropriate safety guidelines when handling or using products containing this ingredient.

Sustainability

The environmental impact of [Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium] salts, such as ambenonium chloride, is not well-documented. However, as with any chemical compound, there is a potential for negative environmental effects if not properly handled and disposed of. In terms of ethical sourcing practices, it is important to ensure that the production of ambenonium chloride and other similar compounds does not involve the exploitation of workers or harm to local communities. It is also important to ensure that the raw materials used in the production of these compounds are sourced responsibly and sustainably. However, information on the specific sourcing practices for ambenonium chloride is not readily available.

Conclusion

In conclusion, ambenonium chloride is a quaternary ammonium compound that functions as a reversible acetylcholinesterase inhibitor, making it useful in the treatment of myasthenia gravis. While it has been shown to be effective in improving muscle strength and reducing symptoms, it can also cause side effects such as gastrointestinal distress and muscle cramps. It is primarily sourced through chemical synthesis and its safety and sustainability are still being studied. Overall, ambenonium chloride is a valuable ingredient in the medical field, but its use should be carefully monitored by healthcare professionals.

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