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Comprehensive Cosmetic Industry Ingredient Guide

THIS IS A UNIVERSAL REFERENCE GUIDE FOR EDUCATIONAL PURPOSES

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Ingredient
APIGENIN

APIGENIN

Summary

Apigenin is a natural flavonoid compound found in various plants, including parsley, chamomile, and celery. It has been shown to possess anti-inflammatory, antioxidant, and anticancer properties, making it a popular ingredient in cosmetic formulations. Apigenin is known to improve skin health by reducing inflammation, protecting against UV damage, and promoting collagen synthesis. It is also effective in reducing the appearance of fine lines and wrinkles, making it a valuable addition to anti-aging skincare products. Overall, apigenin is a versatile and effective cosmetic ingredient that offers numerous benefits for skin health and appearance.

INCI Name and Common References

International Nomenclature of Cosmetic Ingredients name: Apigenin Common terms: None Nicknames: None

Function

Apigenin is a flavonoid compound that is commonly used in cosmetic formulations due to its antioxidant and anti-inflammatory properties. It is known to help protect the skin from damage caused by free radicals and UV radiation, and can also help to soothe and calm irritated skin. In addition, apigenin has been shown to stimulate collagen production, which can help to improve the overall appearance and texture of the skin. As such, it is often included in anti-aging and skin rejuvenation products, as well as in formulations designed to treat acne and other inflammatory skin conditions.

Science

Apigenin is a flavonoid compound that is found in many plants, including parsley, chamomile, and celery. Its physical properties include a molecular weight of 270.24 g/mol, a melting point of 345-350°C, and a solubility in water of 0.002 g/L at 25°C. Apigenin has been shown to have a variety of biological effects, including anti-inflammatory, antioxidant, and anticancer properties. These effects are thought to be due to its ability to interact with various cellular signaling pathways, including those involved in inflammation, oxidative stress, and cell growth and differentiation. One of the ways that apigenin may exert its effects is by binding to and modulating the activity of certain enzymes and receptors in the body. For example, it has been shown to inhibit the activity of an enzyme called COX-2, which is involved in the production of inflammatory molecules in the body. It has also been shown to bind to and activate certain receptors in the body, such as the peroxisome proliferator-activated receptor gamma (PPARγ), which is involved in regulating glucose and lipid metabolism. Overall, the physical properties of apigenin allow it to interact with various cellular targets in the body, leading to a range of biological effects that may be beneficial for human health.

Benefits

- Apigenin is a flavonoid that has anti-inflammatory properties, making it beneficial for reducing redness and irritation in the skin. - It also has antioxidant properties, which can help protect the skin from damage caused by free radicals and environmental stressors. - Apigenin has been shown to stimulate collagen production, which can help improve the skin's elasticity and firmness. - It may also have a brightening effect on the skin, helping to reduce the appearance of dark spots and hyperpigmentation. - Some studies suggest that apigenin may have anti-cancer properties, making it a potentially beneficial ingredient for those with skin cancer or at risk for developing it.

Negatives

Apigenin is a flavonoid compound found in many plants, including parsley, chamomile, and celery. It has been studied for its potential health benefits, including anti-inflammatory and anti-cancer properties. However, like any other ingredient, apigenin may have some side effects, sensitivities, or potential interactions with other ingredients. One of the potential side effects of apigenin is its ability to interact with certain medications. For example, apigenin may interact with blood thinners, such as warfarin, and increase the risk of bleeding. It may also interact with drugs that are metabolized by the liver, such as statins, and affect their effectiveness. Another potential side effect of apigenin is its ability to cause allergic reactions in some people. People who are allergic to other flavonoids, such as quercetin or kaempferol, may also be allergic to apigenin. Symptoms of an allergic reaction may include hives, itching, swelling, and difficulty breathing. In addition, apigenin may have some sensitivities or potential interactions with other ingredients. For example, it may interact with other flavonoids, such as quercetin or kaempferol, and affect their absorption or metabolism. It may also interact with other herbs or supplements that have similar effects, such as St. John's wort or valerian root. Overall, apigenin is a promising ingredient with potential health benefits. However, it is important to be aware of its potential side effects, sensitivities, or potential interactions with other ingredients. If you are considering using apigenin as a supplement or in your diet, it is recommended to consult with a healthcare professional first.

Source

Apigenin is a natural flavonoid that is found in many plants, including parsley, chamomile, and celery. It is derived from the flavone class of flavonoids and is known for its antioxidant and anti-inflammatory properties. The processing pathway for apigenin involves extraction from plant sources, purification, and formulation into supplements or pharmaceuticals. It can also be synthesized in a laboratory setting, but natural sources are preferred due to their higher purity and bioavailability.

Safety

Based on the EWG Skin Deep rating system, Apigenin has a safety score of 1, which is considered to be low hazard. This rating is based on the available data on the ingredient's potential health effects, including its toxicity, carcinogenicity, and developmental and reproductive toxicity. Other sources also suggest that Apigenin is generally safe for use in cosmetics and personal care products. However, as with any ingredient, it is important to use Apigenin in moderation and to follow the recommended usage guidelines to avoid any potential adverse effects.

Sustainability

Apigenin is a flavonoid compound found in many plants, including parsley, chamomile, and celery. While there is limited information available on the environmental impact of apigenin specifically, the production of plants that contain this compound can have both positive and negative effects on the environment. On the positive side, many of the plants that contain apigenin are used in traditional medicine and have been shown to have anti-inflammatory and antioxidant properties. This means that they may be able to help reduce the environmental impact of certain diseases and conditions, such as inflammation caused by pollution or oxidative stress caused by exposure to toxins. However, the production of these plants can also have negative environmental impacts. For example, large-scale farming of parsley or chamomile may require the use of pesticides and fertilizers, which can contribute to soil and water pollution. Additionally, the transportation of these plants from their country of origin to other parts of the world can contribute to greenhouse gas emissions and other environmental problems. In terms of ethical sourcing practices, it is important to ensure that the plants used to produce apigenin are grown and harvested in a sustainable and ethical manner. This may involve working with local farmers to ensure that they are using environmentally friendly farming practices, as well as ensuring that workers are paid fair wages and treated with respect. Additionally, it may be important to work with organizations that are dedicated to protecting the environment and promoting sustainable agriculture, in order to ensure that the production of apigenin is as environmentally friendly and ethical as possible.

Conclusion

In conclusion, apigenin is a flavonoid compound found in various plant sources that has been shown to have numerous health benefits, including anti-inflammatory and anti-cancer properties. While there are some potential negative effects associated with high doses of apigenin, it is generally considered safe for consumption. Additionally, apigenin is a sustainable ingredient that can be sourced from a variety of plants, making it a promising natural alternative to synthetic drugs. Overall, apigenin is a valuable ingredient with significant potential for improving human health.

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