3,3-Bis(4-hydroxyphenyl)phthalide, also known as Phenolphthalein (INN), is a cosmetic ingredient commonly used as a pH adjuster and colorant in various personal care products. It is a white to pale yellow crystalline powder that is soluble in alcohol and ether, but insoluble in water. Phenolphthalein has been shown to have antimicrobial properties and is often used in oral care products such as mouthwashes and toothpastes. However, it has also been associated with potential health risks and is banned for use in cosmetic products in some countries. As with all cosmetic ingredients, proper safety measures and regulatory compliance should be followed when using Phenolphthalein in personal care formulations.
INCI Name: 3,3-Bis(4-hydroxyphenyl)phthalide Common Terms: Phenolphthalein Nicknames: INN
Phenolphthalein is commonly used as a pH indicator in cosmetic formulations. It can also act as a colorant and a preservative. In some cases, it may be used as a laxative in certain cosmetic products.
Phenolphthalein is a pH indicator that works based on its physical properties. It is a weak acid that dissociates in water to form an anion and a proton. The anion is pink in color, while the proton is colorless. In acidic solutions, the equilibrium shifts towards the protonated form, which is colorless. In basic solutions, the equilibrium shifts towards the deprotonated form, which is pink. Therefore, phenolphthalein can be used to determine the pH of a solution by observing the color change.
Unfortunately, there are no skincare benefits associated with 3,3-Bis(4-hydroxyphenyl)phthalide (Phenolphthalein (INN)). In fact, it is not recommended for use in skincare products due to its potential toxicity and carcinogenic properties.
Phenolphthalein (INN), also known as 3,3-Bis(4-hydroxyphenyl)phthalide, is a synthetic organic compound that is commonly used as a laxative and as a pH indicator in laboratory experiments. While it is generally considered safe when used in small amounts, there are some potential side effects, sensitivities, and interactions with other ingredients that should be considered. One of the most common side effects of phenolphthalein is gastrointestinal discomfort, including cramping, nausea, and diarrhea. This is because the compound works by stimulating the muscles in the intestines, which can cause increased bowel movements and fluid loss. In rare cases, more serious side effects such as dehydration, electrolyte imbalances, and kidney damage may occur. Another potential concern with phenolphthalein is its sensitivity to light and air. When exposed to these elements, the compound can break down and form harmful byproducts that may be toxic or carcinogenic. For this reason, it is important to store phenolphthalein in a cool, dark place and to use it only as directed. Finally, there are some potential interactions with other ingredients that should be considered when using phenolphthalein. For example, it may interact with certain medications, such as anticoagulants or diuretics, and may also interfere with the absorption of certain nutrients, such as calcium and iron. Additionally, some people may be allergic or sensitive to phenolphthalein, which can cause skin irritation, respiratory problems, or other adverse reactions. Overall, while phenolphthalein is generally considered safe when used in small amounts, it is important to be aware of its potential side effects, sensitivities, and interactions with other ingredients. If you have any concerns or questions about using this compound, it is always best to consult with a healthcare professional or a qualified laboratory technician.
Origin: Phenolphthalein is a synthetic organic compound that was first synthesized in 1871. Nature: Phenolphthalein is a synthetic compound. Processing Pathway: Phenolphthalein is synthesized by reacting phthalic anhydride with two equivalents of phenol in the presence of a strong acid catalyst. The resulting product is then purified by recrystallization. Phenolphthalein is commonly used as a pH indicator in laboratory experiments and as a laxative in medicine. However, due to its potential carcinogenic properties, it has been banned for use in over-the-counter laxatives in many countries.
Based on the EWG Skin Deep rating system, 3,3-Bis(4-hydroxyphenyl)phthalide (Phenolphthalein (INN)) has a score of 4 out of 10, indicating a moderate safety concern. Other sources also suggest that this ingredient may have potential health risks, including carcinogenicity and reproductive toxicity. As such, it is important to use caution when using products containing this ingredient and to consult with a healthcare professional if you have any concerns.
Phenolphthalein is a synthetic organic compound that is commonly used as a pH indicator in laboratory experiments and as a laxative in medicine. While it is not considered to be a major environmental pollutant, its production and disposal can have negative impacts on the environment. The production of phenolphthalein involves the use of various chemicals and solvents, some of which can be harmful to the environment if not properly managed. Additionally, the disposal of unused or expired phenolphthalein can lead to contamination of water sources and soil. In terms of ethical sourcing practices, it is important to ensure that the production of phenolphthalein does not involve the exploitation of workers or the violation of human rights. However, as phenolphthalein is primarily produced in industrial settings, there may be limited opportunities for ethical sourcing practices to be implemented. Overall, while phenolphthalein may not have a significant environmental impact, it is important to consider the potential negative effects of its production and disposal. Additionally, efforts should be made to ensure that its production does not involve unethical practices.
In conclusion, 3,3-Bis(4-hydroxyphenyl)phthalide, also known as Phenolphthalein, is a chemical compound that has been widely used as a laxative and pH indicator. While it has been shown to have some benefits in promoting bowel movements, it also has potential negative side effects such as gastrointestinal discomfort and carcinogenicity. Phenolphthalein can be found in various sources such as over-the-counter laxatives and dietary supplements. However, due to its potential health risks, it has been banned in several countries. In terms of sustainability, Phenolphthalein is not considered an environmentally friendly ingredient. Overall, it is important to use caution when consuming products containing Phenolphthalein and to consider alternative, safer options for promoting bowel regularity.
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