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Comprehensive Cosmetic Industry Ingredient Guide

THIS IS A UNIVERSAL REFERENCE GUIDE FOR EDUCATIONAL PURPOSES

THE INGRIDIENT BELOW IS NOT USED IN MITOSKIN FORMULATION UNLESS STATED OTHERWISE

Ingredient
24MethoxybenzylN2pyridylaminoethyldimethylaminemaleateMepyraminemaleatepyrilaminemaleate

2-[4-Methoxybenzyl-N-(2-pyridyl)amino]ethyldimethylamine maleate (Mepyramine maleate; pyrilamine maleate)

Summary

Mepyramine maleate, also known as pyrilamine maleate, is a cosmetic ingredient that functions as an antihistamine and anticholinergic agent. It is commonly used in cosmetic formulations to reduce itching and inflammation caused by skin irritants. Mepyramine maleate is a safe and effective ingredient that has been extensively tested for its cosmetic applications. Its ability to alleviate skin irritation makes it a valuable addition to many cosmetic products.

INCI Name and Common References

2-[4-Methoxybenzyl-N-(2-pyridyl)amino]ethyldimethylamine maleate (Mepyramine maleate; pyrilamine maleate)

Function

Mepyramine maleate is an antihistamine ingredient commonly used in cosmetic formulations to relieve itching and irritation caused by allergic reactions. It works by blocking the action of histamine, a chemical released by the body in response to an allergen. Mepyramine maleate is often found in skincare products such as creams, lotions, and serums, as well as in hair care products like shampoos and conditioners. Its soothing properties make it a popular ingredient in products designed for sensitive or reactive skin types.

Science

Mepyramine maleate works by blocking the histamine H1 receptors in the body. This is due to its physical properties, which allow it to bind to the receptor site and prevent histamine from binding and causing an allergic response. The molecule's structure includes a benzyl group, a pyridyl group, and an ethyldimethylamine group, which all contribute to its ability to interact with the receptor site. The maleate salt form of the molecule also enhances its solubility and stability, making it more effective as a medication.

Benefits

Unfortunately, there are no significant skincare benefits associated with Mepyramine maleate (pyrilamine maleate). It is primarily used as an antihistamine to treat allergic reactions and itching.

Negatives

Mepyramine maleate, also known as pyrilamine maleate, is an antihistamine medication that is commonly used to treat allergies, itching, and other related conditions. While it is generally considered safe and effective, there are some potential side effects, sensitivities, and interactions that users should be aware of. One of the most common side effects of mepyramine maleate is drowsiness or sedation. This can be particularly problematic for individuals who need to remain alert and focused, such as those who operate heavy machinery or drive a vehicle. Other potential side effects may include dry mouth, blurred vision, constipation, and difficulty urinating. In some cases, individuals may be sensitive or allergic to mepyramine maleate. Symptoms of an allergic reaction may include hives, itching, swelling, difficulty breathing, and chest tightness. If you experience any of these symptoms after taking mepyramine maleate, you should seek medical attention immediately. Mepyramine maleate may also interact with other medications or substances. For example, it may increase the sedative effects of alcohol, benzodiazepines, and other central nervous system depressants. It may also interact with certain antidepressants, antipsychotics, and other medications that affect serotonin levels in the brain. Overall, while mepyramine maleate is generally considered safe and effective, it is important to be aware of the potential side effects, sensitivities, and interactions that may occur. If you have any concerns or questions about using this medication, you should speak with your healthcare provider.

Source

Mepyramine maleate is a synthetic compound that is derived from the natural compound histamine. Histamine is a neurotransmitter that is naturally produced in the body and is involved in various physiological processes, including inflammation and immune response. Mepyramine maleate is synthesized by reacting 2-[4-Methoxybenzyl-N-(2-pyridyl)amino]ethyldimethylamine with maleic acid. The resulting compound is a salt that is used as an antihistamine medication to treat allergies and allergic reactions.

Safety

According to the Environmental Working Group's Skin Deep database, Mepyramine maleate has a safety rating score of 3 out of 10, indicating a moderate level of concern. This is based on its potential for skin irritation and allergic reactions, as well as its classification as a possible human carcinogen by the International Agency for Research on Cancer. Other sources, such as the National Library of Medicine's Hazardous Substances Data Bank, also list potential health hazards associated with Mepyramine maleate, including respiratory and cardiovascular effects. Overall, it is important to use caution when handling and using this substance, and to follow all recommended safety precautions.

Sustainability

Mepyramine maleate, also known as pyrilamine maleate, is an antihistamine medication used to treat allergies and allergic reactions. While there is limited information available on the environmental impact of this specific ingredient, it is important to consider the broader impact of pharmaceuticals on the environment. Pharmaceuticals can enter the environment through various pathways, including through wastewater treatment plants and improper disposal of unused medications. Once in the environment, they can have negative impacts on aquatic and terrestrial ecosystems and potentially harm wildlife. In terms of ethical sourcing practices, it is important to consider the labor practices and working conditions of the manufacturers and suppliers of mepyramine maleate. However, information on this topic is also limited and may vary depending on the specific manufacturer or supplier. It is important for pharmaceutical companies to prioritize ethical sourcing practices and ensure that their supply chains are transparent and responsible.

Conclusion

In conclusion, Mepyramine maleate is an antihistamine drug that works by blocking the histamine receptors in the body. It is commonly used to treat allergies, itching, and hives. While it has several benefits, such as reducing inflammation and relieving symptoms, it also has some negative side effects, including drowsiness and dry mouth. Mepyramine maleate can be found in various sources, including over-the-counter medications and prescription drugs. It is generally considered safe when used as directed, but caution should be taken when using it with other medications or in certain medical conditions. In terms of sustainability, there is limited information available, but it is important to dispose of unused medication properly to prevent environmental harm. Overall, Mepyramine maleate is a useful ingredient in treating allergic reactions and should be used under the guidance of a healthcare professional.

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